Brotherhood

The Brotherhood is an evil organization bent on world domination and the elimination of heroes founded and formerly led Brian Death, and led by Ghost and his associates Lady Death, General Death, Monsieur Mallus, and Dr. Cyanide, serving as the main antagonists of Season 4 and the archenemies of Sebastian Harper.

Their plan is to eliminate every potential threat like the Legends and take over the world. Hiring and disposing of certain employees, they have been attacking Bianco Academy for years, until focusing on West City and are responsible for the death of Janet Roane. After Ghost seemingly took out the Legends, he lead an assault on the city and caused chaos, capturing the Legends, the Council of Justice, the Arsenals, Team Silver, and Team Zero. After defeating Ghost, who revealed the whereabouts of his friends and the existence of the Brotherhood, Sebastian lead a final assault against the Brotherhood, freeing his friends, avenging Janet, and destroying the Brotherhood of Evil (as nicknamed by Sebastian).

After the fall of the Brotherhood, however one of the last members left, X, gathered the remaining members and currently continues the legacy of the Brotherhood.

History
The Brotherhood and Bianco Academy have clashed on numerous occasions in the past; the only instances recorded in the series involved a device which could be opened and closed in any location of the Brotherhood's choice.

Because of their frequent conflicts, Brian and Dr. Cyanide were gradually able to analyze and predict Bianco Academy's modus operandi, which was further benefited by All Master's slight stubbornness and drive to see a mission finished. Finally, they managed to trap everyone from Bianco Academy (minus All Master, who had retired following a final fight with Ruin) during a mission, where the Brian's forces were scavenging materials to charge a power cell for their newest version of the Arc Capacitor/Portal Generator.

Having finally defeated Bianco Academy, they set their eyes on West City, focusing on expanding their members using nanite infected citizens and incarcerated villains.